The Proteomic Code: a molecular recognition code for proteins
نویسندگان
چکیده
منابع مشابه
A universal code for RNA recognition by PUF proteins.
The design of proteins that can bind any RNA sequence of interest has many potential biological and medical applications. Here we have expanded the recognition of Pumilio and FBF homology protein (PUF) repeats beyond adenine, guanine and uracil and evolved them to specifically bind cytosine. These repeat sequences can be used to create PUF domains capable of selectively binding RNA targets of d...
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• Recessive mutations are due to loss-of-function by the protein product. • Dominant mutations result from a gain-of-function. • Testing whether a gene is essential requires a null mutation (one that completely eliminates its function). • Silent mutations have no effect, either because the base change does not change the sequence or amount of protein, or because the change in protein sequence h...
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* One of the authors (F.R.) was supported by grant PF-244 from the American Cancer Society. Present address: Department of Biochemistry, Michigan State University, East Lansing, Michigan. t Present address: Department of Chemistry, Princeton University, Princeton, New Jersey. 1 Madison, J. T., and R. W. Holley, Biochem. Biophys. Res. Commun., 18, 153 (1965). 2 Zachau, G. F., D. D'Utting, and H....
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ژورنال
عنوان ژورنال: Theoretical Biology and Medical Modelling
سال: 2007
ISSN: 1742-4682
DOI: 10.1186/1742-4682-4-45